The Nike React Infinity Run Flyknit 2 is basically a memory foam mattress for your feet—if that mattress also helped you avoid injuries and run farther. It packs the most React foam of any Nike running shoe, with a chunkier midsole than the React Miler but somehow still lighter than both the Miler and ZoomX.
While it won’t break records on race day, it’s a dream for runners who want to go the distance without their knees complaining. Slip it on, and the ground feels miles away (in the best way). According to Nike’s lab coats, it reduces injuries 52% better than the old-school Air Zoom Structure 22—which is basically Nike’s motion control hall monitor.
The React foam is softer, bouncier, and classier than Cushlon, offering smoother support and stability. Long runs feel less like a joint-punishing punishment and more like a comfortable cruise. Plus, despite the thick stack, it still delivers surprisingly good ground feel—because yes, you can have cushion and connection.
With an 8.4–9 mm heel-to-toe drop and a sleek rocker geometry, the React Infinity Run Flyknit 2 rolls you forward like it’s got cruise control. Compared to the Winflo—Nike’s budget-friendly bruiser—this shoe feels like upgrading from a used hatchback to a smooth-handling luxury ride. After a few runs in the React Infinity 2, going back to the Winflo feels like downgrading to flip-flops with laces.
To be fair, the Winflo does offer solid heel support and feels comfy for casual strolls on pavement. But when it comes to daily runs? The Infinity 2 steals the show with its sportier, more serious runner aesthetic—less “walk the dog,” more “let’s PR this 10K.”
Wide-footed runners will enjoy the roomy toe box, though if your feet are extra wide, the extended heel clip might feel like it’s throwing a surprise party in your midfoot. Some runners say it pokes at the arch—personally, I like the clip’s support, even if it occasionally feels like my foot is being politely nudged back into place.
The heel clip on the Nike React Infinity Run Flyknit 2 acts like a backstage bouncer for your ankle—firm, unflinching, and making sure your foot doesn’t party too hard side-to-side. It’s reminiscent of Brooks’ GuideRails, which is great news for my semi-flat feet. Even on long runs, my knees and hips were shockingly quiet—no complaints, no weird twinges. That’s a win.
That said, this shoe seems to vibe best with neutral runners and supinators. Overpronators like me may find themselves craving a bit more arch support—just a touch more “hug” in the midfoot. It shines brightest on pavement, not the track, and if Nike threw a Zoom Air unit in the forefoot, I might just propose marriage.
The broad base provides extra stability, even when you’re too lazy to fully tie your laces (we’ve all been there). The React outsole pattern delivers squishy comfort, while the added rubber boosts traction—especially handy during wet runs when your feet start to question your life choices.
Some runners say the grip outperforms the Pegasus 38, though the React Miler still holds the crown for traction. One gripe? The midfoot section could use a bit more armor to protect that plush midsole foam—because let’s face it, durability matters when you’re dragging these things through your 400-mile journey.
Now for the Flyknit upper—it’s breathable, snug, and surprisingly comfy compared to ZoomX. The Flywire cables are the unsung heroes, hooking into the laces to give your foot a lockdown fit without making it feel like it’s trapped in a bear hug. Just don’t skip the socks—there’s not much padding in the forefoot, and unless you’re a fan of blisters, it’s better safe than sorry.
The Nike React Infinity Run Flyknit 2 is perfect for casual joggers and seasoned mileage warriors alike. Whether you’re cruising through a Sunday shakeout or grinding through a long-distance run, this shoe brings the cushioning and impact protection that keeps your legs feeling less like overcooked spaghetti. It even picks up the pace decently—though let’s be real, if you’re chasing PRs, you might miss the spring-loaded zing of a Zoom Air unit in the forefoot.
But let’s talk about the one Achilles’ heel of this shoe… ironically, it’s the tongue.
Yes, the tongue. That tiny little fabric tab that seems like it got skipped during design class. It’s short, it’s fragile, and it hides beneath the laces like it’s playing hide-and-seek. During my first wear, I didn’t dare adjust it out of fear I’d Hulk-rip it in half. And I’m not alone—other runners have had this poor little guy tear right down the middle after one enthusiastic yank.
It’s comfy enough under the laces, sure, but functionally, it’s like trying to pull a Band-Aid off a sock. If Nike had just added an inch or two, we could adjust it like civilized humans without resorting to finger yoga.
Final Thoughts on the Nike React Infinity Run Flyknit 2
The Nike React Infinity Run Flyknit 2 is like a bodyguard for your feet—minus the earpiece and sunglasses. It’s a top pick for safety-conscious runners, thanks to its mountain of React foam cushioning, which Nike claims is 52% better at injury prevention than the Air Zoom Structure 22. (Sorry, Structure—maybe next season.)
That React foam? It’s like running on memory foam clouds that bounce back with just the right amount of sass. You’ll get top-tier energy return, long-haul durability, and a ride so smooth, your joints might start sending you thank-you notes.
To top it all off, the breathable Flyknit upper keeps things cool when the temperature climbs—because nobody wants their feet to feel like baked potatoes halfway through a summer run.
Nike React Infinity Run Flyknit 2 FAQs
What is so special about Nike React?
The React foam cushioning is Nike’s longest-lasting foam. It is soft and springy yet supportive and stable. The Nike shoes with React foam usually have a thicker midsole, ideal for even heavier runners. They provide a consistent cushion mile after mile. There is much cushioning in this foam, and it has a good energy return to make your stride easier.
What type of shoe is the Nike Infinity React?
Nike Infinity React is a supportive, neutral running shoe. It is the shoe with the most React foam cushioning. It excels on easy runs but is also comfortable at faster paces. Nike also recommends this shoe for walking.
Is Infinity React good for flat feet?
Yes, Infinity React is good for flat feet. Nike recommends the React foam for overpronation because it provides specific cushioning technology that is soft, springy, and stable. The Infinity React also has a heel clip, which helps secure the rear foot so your ankles won’t have extra movements while running.
Are Nike Reacts comfortable?
Yes. Nike React shoes are comfortable even for heavier runners. They usually have thicker midsoles with remarkable cushioning and shock absorption built for easy runs. But these shoes are not slow and could adjust to your speed.
What is the main purpose of a rocker Nike shoes?
A rocker Nike shoe offers three things to your stride: (1) It offers flexibility at toe-off. (2) It provides a smooth transition from heel to toe to make you run more efficiently. (3) It cushions the foot when it hits the ground.
Are Nike React Infinity Run Flyknit good for wide feet?
Yes. The React Infinity Run can fit regular-sized feet up to wide feet. It also has a roomy toe box with excellent cushioning under the forefoot. However, if you have super-wide feet, you may struggle in the hindfoot because of the heel clip that seems to set the width of the shoe. But the heel clip will somehow adjust to the width of your foot.
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